Description

4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate is a versatile and reactive aromatic isothiocyanate building block, essential for synthesizing advanced chemical intermediates. Its core value lies in the combination of the electrophilic isothiocyanate group with the chloro- and trifluoromethyl substituents, enabling precise molecular modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and pesticides with enhanced activity and selectivity.
• Ligand and Chelator Development: Used to create specialized ligands for catalysis or metal ion chelation in material science.
• Polymer Modification: Serves as a functional monomer or cross-linking agent to introduce specific properties into polymer chains.
• Chemical Biology Probes: Utilized in the design of activity-based probes for studying enzyme function and protein labeling.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized colorants and functional dyes.

Basic Information

Product Name	4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate
CAS No.	23163-86-2
Molecular Formula	C8H3ClF3NS
Molecular Weight	237.63 g/mol
Synonyms	1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene; 4-Chloro-α,α,α-trifluoro-m-tolyl isothiocyanate; 3-Trifluoromethyl-4-chlorophenyl isothiocyanate; 4-Chloro-3-trifluoromethylphenyl isothiocyanate; 2-Chloro-α,α,α-trifluoro-p-tolyl isothiocyanate; Isothiocyanic acid, 4-chloro-3-(trifluoromethyl)phenyl ester; 4-Chloro-α,α,α-trifluoro-m-tolyl mustard oil
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.