Description

Indole-3-Glyoxylyl Chloride is a highly reactive acid chloride derivative of indole-3-glyoxylic acid, serving as a crucial synthetic intermediate. Its primary value lies in enabling the efficient introduction of the indole-3-glyoxyl moiety into target molecules, facilitating the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors, particularly for developing novel indole-based therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of indole-based drug candidates, including potential kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that incorporate indole scaffolds.
• Peptide Mimetics & Bioconjugation: Facilitates the creation of peptide analogs and bioconjugates by reacting with amines to form amide bonds.
• Material Science Research: Employed in the development of organic semiconductors, dyes, and photoactive materials due to its electron-rich indole core.
• Chemical Biology Probes: Acts as a reagent for labeling proteins or synthesizing activity-based probes for enzyme studies.
• Academic & R&D Laboratories: Serves as a versatile reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	Indole-3-Glyoxylyl Chloride
CAS No.	22980-09-2
Molecular Formula	C10H6ClNO2
Molecular Weight	207.61 g/mol
Synonyms	Indole-3-glyoxylic acid chloride; 1H-Indole-3-glyoxylyl chloride; 3-Indoleglyoxylyl chloride; (1H-Indol-3-yl)-oxoacetyl chloride; 2-Oxo-2-(1H-indol-3-yl)acetyl chloride; 3-Indolylglyoxylyl chloride; α-Oxo-1H-indole-3-acetyl chloride
EINECS	Contact for details

Quality Control

Our Indole-3-Glyoxylyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, IR for structural identification, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a recommended temperature of 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as water, alcohols, bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.