Description

Codeine 6-Methanesulfonate is a specific pharmaceutical salt form of the well-known opioid alkaloid codeine. This derivative is primarily valued for its enhanced stability and solubility profile compared to the free base, making it a critical intermediate in the synthesis of high-purity active pharmaceutical ingredients (APIs). It is essential for manufacturers and research institutions in the pharmaceutical sector requiring a reliable and consistent raw material for analgesic formulations, antitussive medications, and advanced pharmacological research.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of codeine-based analgesic and antitussive APIs.
• Analgesic Formulations: Used in the development and production of prescription pain relief medications.
• Antitussive Agents: Integral to the manufacture of cough suppressants.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in laboratories.
• Pharmacological Research: Utilized in preclinical and clinical research studying opioid receptor interactions and metabolic pathways.
• Controlled Substance Synthesis: A regulated precursor in the licensed production of schedule II/III narcotics.

Basic Information

Product Name	Codeine 6-Methylesulfonate
CAS No.	22952-80-3
Molecular Formula	C19H23NO6S
Molecular Weight	393.46 g/mol
Synonyms	Codeine Methanesulfonate; Codeine Mesylate; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol methanesulfonate; Morphine-3-methyl ether methanesulfonate; Codeine 6-(Methylsulfonate); NSC 407787; 6α-Codeine methanesulfonate
EINECS	Contact for details

Quality Control

Our Codeine 6-Methanesulfonate is produced and tested under strict quality management systems. We ensure compliance with current industry standards for pharmaceutical intermediates. Comprehensive testing includes identity, purity, and impurity profile analysis. A Certificate of Analysis (COA) detailing specific results for each batch is provided to guarantee traceability and meet rigorous customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.