Description

Guanylyl 2'-5' Guanosine is a unique dinucleoside monophosphate, a structural isomer of the more common 3'-5' linked oligonucleotides. This compound matters as a critical biochemical tool for studying the mechanisms of interferon action and the 2-5A synthetase/RNase L antiviral pathway. Researchers in pharmaceutical R&D, virology, and immunology require it for investigating innate immune responses and developing novel therapeutic strategies.

Application

• Biochemical Research: A key substrate and reference standard for studying the 2',5'-oligoadenylate (2-5A) synthetase pathway.
• Antiviral Mechanism Studies: Used to investigate the activation of RNase L and its role in degrading viral RNA, a crucial part of the cellular interferon response.
• Enzymology: Serves as a substrate for enzymes like 2',5'-oligoadenylate synthetase to understand enzyme kinetics and specificity.
• Pharmaceutical Development: Acts as a tool compound in screening assays for drugs targeting the interferon-mediated antiviral defense system.
• Diagnostic Reagent Component: Potential use in developing diagnostic kits for monitoring interferon activity or related autoimmune disorders.
• Nucleotide Analog Synthesis: Can be used as a building block or precursor for synthesizing novel nucleotide analogs with potential biological activity.

Basic Information

Product Name	Guanylyl 2'-5' Guanosine
CAS No.	22886-44-8
Molecular Formula	C20H25N10O13P
Molecular Weight	644.44 g/mol
Synonyms	2',5'-GpG; P1-Guanosine-5'-yl P2-guanosine-2'-yl ester; 2'-5' GpG; G(2'-5')G; Guanylyl(2'→5')guanosine; Guanosine 5'-[guanosine 2'-phosphate]; 2',5'-Oligoadenylate dimer core; 2-5A core (GpG)
EINECS	Contact for details

Quality Control

Our Guanylyl 2'-5' Guanosine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research-grade and potential cGMP-grade manufacturing to meet the stringent requirements of pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.