Description

N(3)-Methyl-2'-Deoxycytidine is a modified nucleoside analog of deoxycytidine, featuring a methyl group at the N3 position of the cytosine base. This specific structural modification is of significant interest in biochemical research and pharmaceutical development, particularly for studying DNA methylation, enzyme interactions, and nucleoside metabolism. It serves as a critical building block and reference standard for researchers in medicinal chemistry, molecular biology, and epigenetics. The compound is essential for developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Research & Development: Used as a key intermediate and reference standard in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Studies: Employed in enzymatic assays and studies to investigate the substrate specificity of DNA methyltransferases and other nucleic acid-modifying enzymes.
• Epigenetics Research: Serves as a tool to study the role of cytosine methylation in gene expression regulation and epigenetic mechanisms.
• Medicinal Chemistry: Acts as a building block for creating modified oligonucleotides with tailored properties for therapeutic and diagnostic applications.
• Academic & Industrial R&D: Utilized in universities and corporate R&D labs for fundamental research into DNA structure, function, and damage.
• Quality Control & Analytical Standards: Functions as a high-purity certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	N(3)-Methyl-2'-Deoxycytidine
CAS No.	22882-02-6
Molecular Formula	C10H15N3O4
Molecular Weight	241.25 g/mol
Synonyms	3-Methyl-2'-deoxycytidine; 1-(2-Deoxy-β-D-ribofuranosyl)-3-methyl-2-oxo-1,2-dihydropyrimidin-4-amine; N3-Methyldeoxycytidine; 3-Methyldeoxycytidine; 2'-Deoxy-3-methylcytidine; 3-Methyl-2'-deoxycytidine; N3-Methyl-2'-deoxycytidine
EINECS	Contact for details

Quality Control

Our N(3)-Methyl-2'-Deoxycytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can supply material compliant with various internal specifications for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Long-term storage at -20°C is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.