Description

2'-Deoxy-L-Guanosine is a nucleoside derivative and the L-enantiomer of the naturally occurring D-deoxyguanosine. This compound matters as a critical chiral building block and reference standard in advanced pharmaceutical research and development. It is primarily needed by researchers and manufacturers in the life sciences sector, particularly for applications in antiviral drug development, nucleoside chemistry, and as a biochemical tool for studying enzyme mechanisms and stereospecificity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies to investigate the activity and selectivity of kinases, polymerases, and other nucleoside-processing enzymes.
• Stereochemical Studies: Employed in comparative studies to understand the biological activity and metabolic pathways of D- vs. L-nucleoside enantiomers.
• Antisense Oligonucleotide Development: Acts as a modified nucleoside component in the exploration of stereochemically-defined oligonucleotides for therapeutic applications.
• Diagnostic Reagent Manufacturing: Utilized in the production of specialized reagents and kits for molecular diagnostics and research assays.

Basic Information

Product Name	2'-Deoxy-L-Guanosine
CAS No.	22837-44-1
Molecular Formula	C10H13N5O4
Molecular Weight	267.24 g/mol
Synonyms	L-2'-Deoxyguanosine; (2S)-2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 2'-Deoxy-L-guanosine; L-dG; (-)-2'-Deoxyguanosine; L-Deoxyguanosine; Guanosine, 2'-deoxy-, L-; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one, (2S)-2-amino-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-L-Guanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral identity, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.