Description

Trimethylsilyl Trifluoromethanesulfonate is a highly reactive silylating agent and a powerful Lewis acid catalyst. This compound is valued for its exceptional ability to introduce the trimethylsilyl (TMS) protecting group and to activate a wide range of substrates in organic synthesis. It is a critical reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise and efficient chemical transformations are paramount.

Application

• Protecting Group Chemistry: Efficient silylation of alcohols, phenols, carboxylic acids, and amines to protect functional groups during multi-step synthesis.
• Lewis Acid Catalysis: Facilitating Friedel-Crafts alkylations and acylations, Diels-Alder reactions, and other carbon-carbon bond-forming transformations.
• Polymerization Initiator: Used as a catalyst or co-catalyst in the polymerization of olefins and other monomers for specialty polymers.
• Peptide Synthesis: Employed for the activation of carboxyl groups and as a coupling reagent in solid-phase peptide synthesis (SPPS).
• Glycosylation Reactions: Key reagent for activating glycosyl donors in the synthesis of complex carbohydrates and nucleosides.
• Production of Silicon-Containing Compounds: Serves as a precursor or intermediate in the manufacture of silanes, silicones, and other organosilicon materials.
• Analytical Derivatization: Used to derivative polar compounds for Gas Chromatography (GC) and Mass Spectrometry (MS) analysis to improve volatility and detection.

Basic Information

Product Name	Trimethylsilyl Trifluoromethanesulfonate
CAS No.	22607-77-8
Molecular Formula	C4H9F3O3SSi
Molecular Weight	222.26 g/mol
Synonyms	Trimethylsilyl Triflate; TMSOTf; Trimethylsilyl Trifluoromethanesulphonate; (Trimethylsilyl) Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid Trimethylsilyl Ester; Silicon, Trimethyl(trifluoromethylsulfonyloxy)-; Trimethylsilyl Ester of Trifluoromethanesulfonic Acid
EINECS	245-088-1

Quality Control

Our Trimethylsilyl Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed to meet exacting specifications suitable for research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.24 - 1.28 g/mL
Refractive Index (n20D)	1.360 - 1.370

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.