Description

2-Bromobutyryl Chloride is a versatile and highly reactive organic acid chloride derivative, serving as a critical building block in advanced chemical synthesis. Its value lies in its ability to efficiently introduce the 2-bromobutyryl moiety, a key functional group for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key starting material (KSM) or advanced intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated side chains.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the bromine atom enhances biological activity.
• Peptide Chemistry & Protein Labeling: Acts as an acylating agent for modifying amino groups on peptides or proteins, useful in bioconjugation and probe development.
• Polymer Science: Employed as a monomer or co-monomer in the synthesis of specialized polymers and functional materials.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation, esterification, and amidation reactions to create ketones, esters, and amides.
• Ligand & Catalyst Preparation: Useful for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.

Basic Information

Product Name	2-Bromobutyryl Chloride
CAS No.	22118-12-3
Molecular Formula	C4H6BrClO
Molecular Weight	185.45 g/mol
Synonyms	2-Bromobutanoyl Chloride; Butanoyl Chloride, 2-bromo-; α-Bromobutyryl Chloride; 2-Bromobutyric Acid Chloride; NSC 401123; Butyryl chloride, 2-bromo-; 2-Bromobutyroyl Chloride
EINECS	244-775-9

Quality Control

Our 2-Bromobutyryl Chloride is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat, ignition sources, and incompatible materials such as strong bases, alcohols, and amines. Recommended storage temperature is 2-8°C for extended stability. The container must be kept tightly sealed in a dry inert atmosphere due to its moisture-sensitive and corrosive nature.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.