Description

(22R)-18-Acetoxy-5,6β-Epoxy-4β,22-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid δ-Lactone is a complex, high-purity steroidal lactone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced intermediate or reference standard for the synthesis and study of novel bioactive molecules. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or probe in studies of enzyme inhibition, receptor binding, and metabolic pathways.
• Reference Material: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Academic Research: Employed in university and institutional labs for chemical synthesis projects and structure-activity relationship (SAR) studies.
• Process Development: Utilized in scaling up synthetic routes for potential new chemical entities (NCEs) in pilot plants.

Basic Information

Product Name	(22R)-18-Acetoxy-5,6β-Epoxy-4β,22-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid δ-Lactone
CAS No.	21902-99-8
Molecular Formula	C₃₀H₄₀O₇
Molecular Weight	512.64 g/mol
Synonyms	18-Acetoxy-5,6β-epoxy-4β,22-dihydroxy-1-oxo-5β-ergosta-2,24-dien-26-oic acid δ-lactone; (22R)-Ergosta-2,24-dien-26-oic acid derivative; 5,6β-Epoxyergosta-δ²⁴(28)-dien-26-oic acid lactone; 18-O-Acetyl-5,6α-epoxy-4β,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone; NSC 122180; A starting material for Withanolide analogs.
EINECS	Contact for details

Quality Control

Our (22R)-18-Acetoxy-5,6β-Epoxy-4β,22-Dihydroxy-1-Oxo-5β-Ergosta-2,24-Dien-26-Oic Acid δ-Lactone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.