Description

2-Chloro-5-Fluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 2-chloro-5-fluorobenzoyl moiety, a key structural motif in the development of active pharmaceutical ingredients and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating complex organic molecules used in electronic displays and optoelectronic devices.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce specific functional groups into polymer chains, altering material properties.
• Dyestuff and Pigment Manufacturing: Acts as an intermediate in the synthesis of high-performance, light-fast dyes and organic pigments.
• Custom Synthesis & Contract Research: A valuable reagent for research organizations and CDMOs (Contract Development and Manufacturing Organizations) engaged in custom synthesis projects.

Basic Information

Product Name	2-Chloro-5-Fluorobenzoyl Chloride
CAS No.	21900-51-6
Molecular Formula	C7H3Cl2FO
Molecular Weight	193.00 g/mol
Synonyms	2-Chloro-5-fluorobenzoic acid chloride; 5-Fluoro-2-chlorobenzoyl chloride; Benzoic acid, 2-chloro-5-fluoro-, chloride; 2-Chloro-5-fluorobenzenecarbonyl chloride; α,2-Dichloro-α-fluorotoluene (obsolete); 2-Chloro-5-fluorobenzoylchloride; 2-Chloro-5-fluoro-benzoyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluorobenzoyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from GC, HPLC, and NMR analyses, is supplied with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, alcohols, and amines. Due to its hygroscopic and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.