Description

5-Fluoro-2-Methylbenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 5-fluoro-2-methylbenzoyl moiety, enabling the development of compounds with tailored biological and physical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring a fluorinated benzoyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances lipophilicity and target binding.
• Liquid Crystal & OLED Material Production: Acts as a building block for fluorinated aromatic cores in electronic and display materials, improving thermal stability and optical properties.
• Polymer Modification: Employed to introduce functional side chains into polymers, altering characteristics like solubility, glass transition temperature, and chemical resistance.
• Dyestuff and Pigment Manufacturing: Serves as an intermediate for creating specialized, light-fast fluorinated dyes and pigments.
• Custom Synthesis & R&D: A valuable reagent for contract research organizations and academic labs exploring new fluorinated compounds in medicinal and material chemistry.

Basic Information

Product Name	5-Fluoro-2-Methylbenzoyl Chloride
CAS No.	21900-39-0
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	2-Methyl-5-fluorobenzoyl chloride; 5-Fluoro-o-toluoyl chloride; 5-Fluoro-2-methylbenzoic acid chloride; 2-Methyl-5-fluorobenzoic acid chloride; α,5-Difluoro-o-toluoyl chloride (incorrect but sometimes listed); 5-Fluoro-2-methylbenzoyl chloride; 21900-39-0; 5-Fluoro-2-methyl-benzoic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methylbenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.