Description

4-Bromo-3-Methylbenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to efficiently introduce the 4-bromo-3-methylbenzoyl moiety, enabling the construction of complex molecules with tailored properties. This intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a halogenated benzoyl group.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the bromine and methyl substituents can modulate biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating advanced organic electronic materials and liquid crystal compounds.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce specific functional groups into polymer chains, enhancing material properties.
• Dyestuff and Pigment Manufacturing: Intermediate for synthesizing complex dyes and organic pigments.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.
• Peptide Mimetics & Bioconjugation: Used to acylate amines in the development of peptide analogs or for bioconjugation techniques.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and novel compounds.

Basic Information

Product Name	4-Bromo-3-Methylbenzoyl Chloride
CAS No.	21900-25-4
Molecular Formula	C8H6BrClO
Molecular Weight	233.49 g/mol
Synonyms	3-Methyl-4-bromobenzoyl chloride; 4-Bromo-m-toluoyl chloride; 4-Bromo-3-methylbenzoic acid chloride; (4-Bromo-3-methylphenyl)carbonyl chloride; 4-Bromo-3-methyl-benzoylchlorid; Benzoyl chloride, 4-bromo-3-methyl-; α-Chloro-4-bromo-3-methylbenzaldehyde (obsolete); Toluoyl chloride, 4-bromo-
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Methylbenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the high standards required for pharmaceutical and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture. Store away from incompatible materials such as strong oxidizers, bases, and sources of heat or ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.