Description

14-Hydroxy-3,19-Dioxobufa-4,20,22-Trienolide is a specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of cardiovascular and oncological treatments.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel bufadienolide-based drug candidates.
• Biochemical Research: Used as a reference standard or active compound in studies of Na+/K+-ATPase inhibition and related cellular signaling pathways.
• Cardiovascular Research: Investigated for its potential effects on heart muscle contractility and as a template for cardiac glycoside analogs.
• Oncology Research: Explored for its cytotoxic properties and potential application in anti-cancer drug discovery programs.
• Standards & Calibration: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	14-Hydroxy-3,19-Dioxobufa-4,20,22-Trienolide
CAS No.	21887-06-9
Molecular Formula	C₂₄H₃₀O₆
Molecular Weight	414.50 g/mol
Synonyms	14-Hydroxy-3,19-dioxobufa-4,20,22-trienolide; 3β,14-Dihydroxy-19-oxobufa-4,20,22-trienolide; 19-Oxocinobufagin; 19-Oxocinobufotalin; Cinobufagin 19-aldehyde; Bufadienolide derivative 21887-06-9
EINECS	Contact for details

Quality Control

Our 14-Hydroxy-3,19-Dioxobufa-4,20,22-Trienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.