Description

8-Bromoguanosine 5'-Phosphate is a modified nucleotide monophosphate where a bromine atom is introduced at the 8-position of the guanine base. This specific halogenation makes it a valuable biochemical tool and a key synthetic intermediate for studying nucleic acid structure, function, and for the development of nucleotide-based therapeutics. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic assay production. The compound is supplied with high purity to ensure reliable and reproducible results in sensitive applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly with kinases, polymerases, and phosphodiesterases to investigate nucleotide metabolism and signaling pathways.
• Nucleic Acid Probe Synthesis: Serves as a modified building block for the chemical or enzymatic synthesis of oligonucleotide probes, enhancing stability or enabling specific detection methods.
• Pharmaceutical Intermediate: Acts as a crucial precursor in the synthesis of novel antiviral or anticancer nucleoside analogs, where bromination is a key synthetic step.
• Structural Biology Studies: Incorporated into RNA or DNA to study the effects of base modification on nucleic acid conformation, stability, and protein-nucleic acid interactions via X-ray crystallography or NMR.
• Diagnostic Reagent Manufacturing: Employed in the production of key components for diagnostic kits that detect specific enzymes or metabolic markers related to nucleotide cycles.
• Enzyme Mechanism Elucidation: Useful as an analog of GTP or GDP to probe the active sites and catalytic mechanisms of G-proteins and GTPases.

Basic Information

Product Name	8-Bromoguanosine 5'-Phosphate
CAS No.	21870-09-7
Molecular Formula	C10H13BrN5O8P
Molecular Weight	442.12 g/mol
Synonyms	8-Bromo-GMP; 8-Bromoguanosine monophosphate; 8-Br-GMP; Guanosine, 8-bromo-, 5'-(dihydrogen phosphate); 8-Bromoguanosine 5'-monophosphoric acid; 8-Bromo-5'-GMP; 8-Bromoguanosine 5'-(dihydrogen phosphate); 5'-GMP-8-Br
EINECS	Contact for details

Quality Control

Our 8-Bromoguanosine 5'-Phosphate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and synthesis. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.