Description

3β,8,14-Trihydroxybufa-4,20,22-Trienolide is a specialized bufadienolide compound with a complex steroidal structure. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac glycosides and their biological activities. It is primarily sought by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced synthetic chemistry and drug discovery programs.

Application

• Pharmaceutical Research Intermediate: Serves as a key building block in the synthesis and study of novel cardiac glycosides and related therapeutic agents.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for the identification and quantification of bufadienolides.
• Biochemical Research: Employed in in-vitro studies to investigate Na+/K+-ATPase inhibition, cell signaling pathways, and potential cytotoxic effects.
• Natural Product Chemistry: A subject of study for the isolation, characterization, and derivatization of compounds from natural sources like toad venom.
• Preclinical Development: Utilized in early-stage drug discovery for evaluating pharmacokinetic and pharmacodynamic properties of bufadienolide analogs.

Basic Information

Product Name	3β,8,14-Trihydroxybufa-4,20,22-Trienolide
CAS No.	21857-63-6
Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.51 g/mol
Synonyms	3β,8β,14-Trihydroxy-5β-bufa-20,22-dienolide; Bufalin derivative; 3β,8,14-Trihydroxybufa-4,20,22-trienolide; 5β-Bufa-20,22-dienolide-3β,8β,14-triol; Telocinobufagin isomer; Arenobufagin related compound; Bufadienolide intermediate; 21857-63-6
EINECS	Contact for details

Quality Control

Our 3β,8,14-Trihydroxybufa-4,20,22-Trienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.