Description

5-(Trifluoromethyl)-Uridine is a modified nucleoside analog where a trifluoromethyl group is introduced at the 5-position of the uracil base. This compound is a critical building block in medicinal chemistry and life science research, valued for its ability to impart unique metabolic stability and lipophilicity to oligonucleotides and other bioactive molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in drug discovery, antisense therapy, and the development of novel biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of antiviral and anticancer nucleoside analogs.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified bases into oligonucleotides to enhance target binding affinity and nuclease resistance.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleic acid interactions.
• Diagnostic Probe Development: Employed in the creation of labeled nucleotides for use in fluorescence in situ hybridization (FISH) and other detection assays.
• siRNA and miRNA Research: Incorporated into RNA strands to study gene silencing mechanisms and improve therapeutic RNA stability.
• Medicinal Chemistry Library Construction: A valuable scaffold for generating diverse compound libraries for high-throughput screening against various biological targets.

Basic Information

Product Name	5-(Trifluoromethyl)-Uridine
CAS No.	21618-67-7
Molecular Formula	C10H11F3N2O6
Molecular Weight	312.20 g/mol
Synonyms	5-Trifluoromethyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-(trifluoromethyl)pyrimidine-2,4-dione; 2',3',5'-Tri-O-acetyl-5-trifluoromethyluridine (precursor); 5-CF3-Uridine; 5-Trifluoromethyl-1-β-D-ribofuranosyluracil; 5-(Trifluoromethyl)-1-β-D-ribofuranosyluracil; Uridine, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-Uridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment ensures material consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.