Description

N(3)-Ethylthymidine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. This compound is valued for its role in the synthesis of novel antiviral and anticancer agents, where structural modifications at the nucleobase can significantly alter biological activity and pharmacokinetic properties. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers engaged in developing nucleoside-based therapeutics and advanced molecular probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of modified nucleoside analogs for antiviral and anticancer drug discovery programs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA metabolism and repair mechanisms.
• Pro-drug Development: Serves as a scaffold for creating pro-drugs with enhanced cellular uptake and metabolic stability.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotide chains to modulate binding affinity and nuclease resistance.
• Labeled Compound Synthesis: A starting material for preparing isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing studies.
• Academic & Industrial R&D: Fundamental research tool in universities and biotech companies exploring nucleic acid chemistry and biology.

Basic Information

Product Name	N(3)-Ethylthymidine
CAS No.	21473-40-5
Molecular Formula	C12H18N2O5
Molecular Weight	270.28 g/mol
Synonyms	3-Ethylthymidine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-3-ethylpyrimidine-2,4(1H,3H)-dione; 3-Ethyl-5-methyluridine; 3-N-Ethylthymidine; Thymidine, 3-ethyl-; 5-Methyl-3-ethyluridine
EINECS	Contact for details

Quality Control

Our N(3)-Ethylthymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.