Description

N(3)-Benzylthymidine is a chemically modified nucleoside derivative, specifically a thymidine analog with a benzyl group at the N3 position. This structural modification is critical for its role as a versatile building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research scientists and process chemists in the fields of nucleoside chemistry, antiviral drug development, and oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified monomer for incorporating specific functionalities into DNA/RNA strands for research and therapeutic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving thymidine kinases and other nucleoside-metabolizing enzymes.
• Probe and Diagnostic Development: Acts as a starting material for creating labeled nucleosides used in molecular diagnostics and imaging.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic & Industrial R&D: Fundamental research tool in chemistry and biology departments for exploring nucleic acid chemistry and drug discovery.

Basic Information

Product Name	N(3)-Benzylthymidine
CAS No.	21473-21-2
Molecular Formula	C₁₇H₂₀N₂O₅
Molecular Weight	332.35 g/mol
Synonyms	3-Benzylthymidine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-3-(phenylmethyl)pyrimidine-2,4(1H,3H)-dione; 3-Benzyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; N3-Benzylthymidine; Thymidine, 3-benzyl-; Benzylthymidine
EINECS	Contact for details

Quality Control

Our N(3)-Benzylthymidine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.