Description

(3S,11E)-3,4,5,6,9,10-Hexahydro-3-Methyl-14,16-Bis[(Trimethylsilyl)Oxy]-1H-2-Benzoxacyclotetradecin-1,7(8H)-Dione is a complex, high-purity macrolide derivative featuring trimethylsilyl-protected hydroxyl groups. This compound is a critical advanced pharmaceutical intermediate valued for its specific stereochemistry and functional groups, which are essential for constructing sophisticated active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in oncology and anti-infective drug discovery.

Application

• Key Intermediate in Macrolide Antibiotic Synthesis: Serves as a crucial building block for the development of next-generation macrolide antibiotics.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the design and synthesis of novel drug candidates with complex polyketide backbones.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for the commercial production of target APIs.
• Chemical Biology Studies: Acts as a probe or precursor in studying biological pathways and mechanisms of action.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(3S,11E)-3,4,5,6,9,10-Hexahydro-3-Methyl-14,16-Bis[(Trimethylsilyl)Oxy]-1H-2-Benzoxacyclotetradecin-1,7(8H)-Dione
CAS No.	21381-15-7
Molecular Formula	C26H42O6Si2
Molecular Weight	506.78 g/mol
Synonyms	14,16-Bis-O-(trimethylsilyl)-3-deoxy-3-oxo-5-O-mycaminosyltylonolide; 3-Deoxy-3-oxo-5-O-mycaminosyltylonolide 14,16-bis(trimethylsilyl) ether; Tylosin derivative, 14,16-bis-TMS; 14,16-Bis(trimethylsilyl)tylosin derivative; 3-Oxotylactone bis-TMS ether; (3S,11E)-3,4,5,6,9,10-Hexahydro-3-methyl-14,16-bis(trimethylsiloxy)-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications, ensuring traceability and documentation meet rigorous industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.