Description

3'-Acetylthymidine is a key nucleoside derivative and a vital building block in organic synthesis and pharmaceutical research. Its primary value lies in its role as a protected intermediate for the production of modified oligonucleotides and nucleotide analogs. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly those developing antiviral agents, diagnostic probes, and novel therapeutic nucleic acids.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protected monomer in solid-phase and solution-phase synthesis of modified DNA/RNA strands.
• Biochemical Research: Used in studies of enzyme mechanisms, nucleic acid metabolism, and as a substrate for kinases and other modifying enzymes.
• Prodrug Development: The acetyl group can be utilized in prodrug strategies to enhance the bioavailability of therapeutic nucleosides.
• Diagnostic Reagent Manufacturing: A precursor for labeled nucleotides used in sequencing, PCR, and other molecular biology techniques.
• Fine Chemical Synthesis: Valuable chiral synthon for the preparation of complex natural products and specialized organic molecules.

Basic Information

Product Name	3'-Acetylthymidine
CAS No.	21090-30-2
Molecular Formula	C₁₂H₁₆N₂O₆
Molecular Weight	284.26 g/mol
Synonyms	1-[(2R,3S,5R)-3-Acetyloxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Thymidine 3'-acetate; 3'-O-Acetylthymidine; 3'-Acetyl-2'-deoxythymidine; 2'-Deoxythymidine 3'-acetate; 3'-Acetyl-1-(2-deoxy-β-D-ribofuranosyl)thymine
EINECS	Contact for details

Quality Control

Our 3'-Acetylthymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.