Description

Dimethyl L-Isothiocyanatosuccinate is a specialized chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its core value lies in its bifunctional structure, incorporating both an isothiocyanate group and a diester moiety, which enables its use in the construction of complex, biologically active molecules. This high-purity compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel heterocycles and chiral derivatives.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of chiral thiourea derivatives and heterocyclic compounds with potential therapeutic activity.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the isothiocyanate functionality.
• Peptidomimetics & Conjugation: Serves as a versatile linker or coupling agent for modifying peptides and proteins via reaction with amine groups.
• Asymmetric Synthesis: Employed as a chiral scaffold or reagent in stereoselective reactions to introduce sulfur-containing functionalities.
• Chemical Biology Probes: Useful for creating activity-based probes (ABPs) to study enzyme function and mechanism.
• Material Science: Investigated as a monomer or cross-linking agent for specialty polymers with unique properties.

Basic Information

Product Name	Dimethyl L-Isothiocyanatosuccinate
CAS No.	21055-49-2
Molecular Formula	C7H9NO4S
Molecular Weight	203.21 g/mol
Synonyms	L-Aspartic acid, N-isothiocyanato-, dimethyl ester; (2S)-2-Isothiocyanatobutanedioic acid dimethyl ester; Dimethyl (2S)-2-isothiocyanatosuccinate; (S)-Dimethyl 2-isothiocyanatosuccinate; L-Isothiocyanatosuccinic Acid Dimethyl Ester; NSC 163049; NCS-Asp(OMe)-OMe
EINECS	Contact for details

Quality Control

Our Dimethyl L-Isothiocyanatosuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥97% by HPLC), and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.