Description

14β,15β-Epoxy-3β-[(8-Methoxy-1,8-Dioxooctyl)Oxy]-5β-Bufa-20,22-Dienolide is a high-purity, specialized bufadienolide derivative, a class of compounds known for their significant biological activity. This compound serves as a critical advanced pharmaceutical intermediate and a valuable reference standard for research and development. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in the fields of cardiology and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel bufadienolide-based drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical research and manufacturing.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of cardiac glycosides and related compounds.
• Lead Compound Optimization: Utilized in medicinal chemistry for the derivatization and optimization of bioactive molecules.
• Academic Research: Serves as a precise chemical tool in university and institutional labs for pharmacological and toxicological studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	14β,15β-Epoxy-3β-[(8-Methoxy-1,8-Dioxooctyl)Oxy]-5β-Bufa-20,22-Dienolide
CAS No.	20987-32-0
Molecular Formula	C₃₃H₄₆O₈
Molecular Weight	570.72 g/mol
Synonyms	14β,15β-Epoxy-3β-[(8-methoxy-1,8-dioxooctyl)oxy]-5β-bufa-20,22-dienolide; 3β-[(8-Methoxy-1,8-dioxooctyl)oxy]-14β,15β-epoxy-5β-bufa-20,22-dienolide; Bufadienolide derivative; 20987-32-0; 14,15-Epoxy-3-(8-methoxy-1,8-dioxooctyloxy)bufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 14β,15β-Epoxy-3β-[(8-Methoxy-1,8-Dioxooctyl)Oxy]-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.