Description

Cyclopropanecarbonyl Bromide (8Ci,9Ci) is a versatile and highly reactive organic bromide building block, essential for advanced chemical synthesis. Its value lies in the cyclopropane ring, which introduces unique steric and electronic properties into target molecules, enabling the development of novel compounds with specific biological or material characteristics. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing cyclopropane motifs for enhanced metabolic stability and receptor binding.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the cyclopropane group can improve efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for cyclopropanation reactions, acylations, and as a precursor for other cyclopropane derivatives.
• Ligand and Catalyst Development: Useful for synthesizing chiral ligands and organometallic catalysts used in asymmetric synthesis.
• Fluorinated Compound Synthesis: Acts as a starting material for the preparation of fluorocyclopropane derivatives, which are valuable in medicinal chemistry.

Basic Information

Product Name	Cyclopropanecarbonyl Bromide (8Ci,9Ci)
CAS No.	20905-31-1
Molecular Formula	C4H5BrO
Molecular Weight	148.99 g/mol
Synonyms	Cyclopropanecarbonyl bromide; Cyclopropanoyl bromide; Cyclopropanecarboxylic acid bromide; Bromocyclopropanecarboxaldehyde; 1-Bromocarbonylcyclopropane; Cyclopropanecarboxaldehyde, bromo-; Cyclopropanecarboxylic acid, bromide; (Bromocarbonyl)cyclopropane
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Bromide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.