Description

3'-O,5'-o-Dibenzoyl-2'-Deoxyadenosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis and pharmaceutical research. This compound is critical for researchers and manufacturers requiring precise control over nucleotide chemistry, enabling the development of novel therapeutics and diagnostic tools. It is primarily utilized by biotech and pharmaceutical companies engaged in the synthesis of antisense oligonucleotides, siRNA, and other nucleic acid-based drugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the solid-phase synthesis of therapeutic oligonucleotides, including antisense drugs and aptamers.
• Research & Development: Used in academic and industrial labs for studying nucleic acid structure, function, and for developing novel nucleotide analogs.
• Prodrug Synthesis: Serves as a protected precursor in the development of nucleoside prodrugs, enhancing drug stability and bioavailability.
• Diagnostic Probe Development: Employed in the creation of labeled nucleotides for use in diagnostic assays and genomic sequencing technologies.

Basic Information

Product Name	3'-O,5'-o-Dibenzoyl-2'-Deoxyadenosine
CAS No.	20838-22-6
Molecular Formula	C24H21N5O5
Molecular Weight	459.46 g/mol
Synonyms	2'-Deoxyadenosine, 3',5'-bis(benzoyl)-; 3',5'-Di-O-benzoyl-2'-deoxyadenosine; 2'-Deoxy-3',5'-di-O-benzoyladenosine; 3',5'-Dibenzoyl-2'-deoxyadenosine; 2'-Deoxyadenosine 3',5'-dibenzoate; N6-Benzoyl-2'-deoxyadenosine 3',5'-dibenzoate (common protected form); dA(Bz) (abbreviation in oligonucleotide synthesis); Protected 2'-Deoxyadenosine Derivative
EINECS	Contact for details

Quality Control

Our 3'-O,5'-o-Dibenzoyl-2'-Deoxyadenosine is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. The container should be kept tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.