Description

Adenosine 5'-Phosphoroimidazolide is a high-purity, activated nucleotide derivative essential for non-enzymatic RNA synthesis and phosphorylation studies. This compound serves as a critical reagent for the chemical synthesis of oligonucleotides and the investigation of prebiotic chemistry pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on nucleic acid chemistry, molecular biology, and origins-of-life research.

Application

• Non-enzymatic RNA Synthesis: A key monomer for template-directed primer extension studies in prebiotic chemistry and origins-of-life research.
• Chemical Phosphorylation Agent: Used to introduce phosphate groups into nucleosides, nucleotides, and other biomolecules under controlled conditions.
• Oligonucleotide Synthesis Intermediate: Serves as an activated building block in the solid-phase or solution-phase chemical synthesis of DNA and RNA analogs.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog for kinases and other ATP-utilizing enzymes.
• Pharmaceutical Development: Used in the research and development of nucleotide-based therapeutics, including antisense oligonucleotides and aptamers.
• Catalysis Studies: Investigated for its role in metal-ion catalyzed phosphorylation reactions relevant to biochemical evolution.

Basic Information

Product Name	Adenosine 5'-Phosphoroimidazolide
CAS No.	20816-58-4
Molecular Formula	C13H17N6O6P
Molecular Weight	384.29 g/mol
Synonyms	5'-Adenylyl imidazolide; Imidazolide of adenosine 5'-phosphate; P1-(5'-Adenosyl)-P2-imidazolyl diphosphate; Adenosine 5'-(imidazolylphosphate); Ado-5'-plm; AMP-Imidazolide; Adenosine 5'-monophosphorimidazolide
EINECS	Contact for details

Quality Control

Our Adenosine 5'-Phosphoroimidazolide is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our production environment is designed to meet the rigorous demands of biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.