Description

2'-C-Methylcytidine is a chemically modified nucleoside analog that serves as a critical building block in pharmaceutical research and development. Its primary value lies in its role as a key intermediate for the synthesis of antiviral and anticancer nucleotide prodrugs, enabling targeted therapeutic action. This high-purity compound is essential for research institutions, pharmaceutical companies, and CROs/CMOs engaged in the development of next-generation antiviral therapies, particularly against RNA viruses.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of nucleoside-based antiviral drugs, including protease inhibitors and polymerase inhibitors.
• Antiviral Research: Used in biochemical and virological studies to investigate mechanisms of viral replication and inhibition.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Nucleotide Prodrug Development: Key starting material for creating prodrugs designed to improve cellular uptake and metabolic stability.
• Biochemical Reagent: Employed in enzymatic assays and as a substrate for studying nucleoside-metabolizing enzymes.
• GMP Manufacturing: Supplied under controlled conditions for use in the cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2'-C-Methylcytidine
CAS No.	20724-73-6
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	2'-C-Methylcytidine; 1-(2-C-Methyl-β-D-ribofuranosyl)cytosine; 2'-Methylcytidine; 2'-C-Me-Cytidine; NSC 122023; Cytidine, 2'-C-methyl-; 4-Amino-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 2'-C-Methylcytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.