Description

3'-β-C-Methylcytidine is a modified nucleoside analog of cytidine, featuring a methyl group at the 3'-beta carbon position of the ribose sugar. This structural modification is of significant interest in pharmaceutical research, particularly for its role as a key intermediate in the synthesis of antiviral and anticancer nucleotide prodrugs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics targeting viral polymerases and other nucleoside-processing enzymes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced nucleotide analogs with antiviral or anticancer activity.
• Antiviral Drug Research: Used in the development of prodrugs targeting RNA viruses, such as Hepatitis C Virus (HCV), where modified nucleosides act as chain terminators.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand the mechanism of viral polymerases and cellular nucleic acid metabolism.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency, selectivity, and metabolic stability of nucleoside-based drug candidates.
• Pre-clinical Development: Used in the synthesis of compounds for pharmacokinetic, toxicology, and efficacy studies.

Basic Information

Product Name	3'-β-C-Methylcytidine
CAS No.	20724-72-5
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	3'-C-Methylcytidine; 3'-Methylcytidine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-β-C-Methylcytidine; β-3'-Methylcytidine; 3'-Methyl-Cytidine; Cytidine, 3'-C-methyl-
EINECS	Contact for details

Quality Control

Our 3'-β-C-Methylcytidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.