Description

4',5'-Didehydro-5'-Deoxyadenosine CAS NO 20535-04-0 is a chemically modified nucleoside analog of deoxyadenosine, characterized by the presence of a didehydro modification on the sugar moiety. This structural feature makes it a valuable intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel antiviral agents, anticancer compounds, and other therapeutic nucleoside analogs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies, particularly those involving nucleoside metabolism and DNA/RNA synthesis pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Academic Research: Employed in universities and research institutes for studying nucleic acid chemistry and the mechanism of action of nucleoside analogs.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Product Name	4',5'-Didehydro-5'-Deoxyadenosine
CAS No.	20535-04-0
Molecular Formula	C₁₀H₁₁N₅O₃
Molecular Weight	249.23 g/mol
Synonyms	4',5'-Didehydro-5'-deoxyadenosine; 9-[(2R,4S)-2-(Hydroxymethyl)-4,5-dihydro-2H-furan-4-yl]-9H-purin-6-amine; 5'-Deoxy-4',5'-didehydroadenosine; 4',5'-Unsaturated-5'-deoxyadenosine; 4',5'-Didehydro-5'-deoxyadenosine (minor tautomer); 4',5'-Didehydro-5'-deoxyadenosine (major tautomer); 4',5'-Didehydro-5'-deoxyadenosine (common name)
EINECS	Contact for details

Quality Control

Our 4',5'-Didehydro-5'-Deoxyadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.