Description

6-Aza-2'-Deoxyuridine is a synthetic nucleoside analog, a modified form of deoxyuridine where a nitrogen atom replaces the carbon at the 6-position of the uracil base. This structural modification is significant as it confers unique biochemical properties, making it a valuable intermediate and research tool in medicinal chemistry and molecular biology. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of antiviral and anticancer agents, as well as for biochemical studies involving nucleic acid metabolism and enzyme inhibition.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for thymidylate synthase and other enzymes involved in pyrimidine metabolism.
• Antiviral Agent Development: Investigated for its potential activity against DNA viruses due to its ability to be incorporated into viral DNA.
• Molecular Biology Tool: Employed in studies of DNA replication, repair mechanisms, and to induce specific genetic mutations in experimental systems.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Product Name	6-Aza-2'-Deoxyuridine
CAS No.	20500-29-2
Molecular Formula	C8H11N3O5
Molecular Weight	229.19 g/mol
Synonyms	6-Aza-2'-deoxyuridine; 6-Azadeoxyuridine; 2'-Deoxy-6-azauridine; 1-(2-Deoxy-β-D-ribofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine; 6-Aza-dUrd; NSC 5109; 6-Aza-2'-dUrd; 6-AzadU
EINECS	243-879-6

Quality Control

Our 6-Aza-2'-Deoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.