Description

(S)-(+)-α-Methoxy-α-Trifluoromethylphenylacetyl Chloride CAS NO 20445-33-4 is a high-value chiral derivatizing agent and a key building block in asymmetric synthesis. Its primary value lies in its ability to resolve enantiomers of amines, alcohols, and other chiral compounds, which is critical for producing single-enantiomer pharmaceuticals and agrochemicals. This compound is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity chiral intermediates for advanced synthesis.

Application

• Chiral Derivatizing Agent (CDA): For the resolution and analytical determination of enantiomeric purity of amines, amino acids, and alcohols via NMR or HPLC.
• Asymmetric Synthesis: As a chiral auxiliary or reagent in the synthesis of enantiomerically pure pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Pharmaceutical Research: Key building block in the development of chiral drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Fine Chemical Production: For the preparation of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Academic & Industrial R&D: A standard reagent in methodological development for new asymmetric catalytic processes and chiral analysis.

Basic Information

Product Name	(S)-(+)-α-Methoxy-α-Trifluoromethylphenylacetyl Chloride
CAS No.	20445-33-4
Molecular Formula	C11H10ClF3O2
Molecular Weight	266.64 g/mol
Synonyms	(S)-(+)-MTPA-Cl; (S)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride; (S)-Mosher's acid chloride; (S)-MTPA Chloride; (S)-O-Methylmandeloyl chloride, α-trifluoromethyl-; (S)-2-Methoxy-2-(trifluoromethyl)-2-phenylacetyl chloride; (S)-Methoxy(trifluoromethyl)phenylacetyl chloride; L-MTPA-Cl
EINECS	Contact for details

Quality Control

Our (S)-(+)-α-Methoxy-α-Trifluoromethylphenylacetyl Chloride is manufactured under strict quality control protocols to ensure high chemical and optical purity, which is paramount for chiral applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess (ee), and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced synthetic chemistry customers globally.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and its moisture sensitivity, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (ee) (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.