Description

1-Cyano-1-Phenyl-2,2,2-Trifluoroethanol is a versatile fluorinated organic building block characterized by its unique combination of a cyano group, a phenyl ring, and a trifluoroethanol moiety. This compound is highly valued in advanced organic synthesis for its role as a key chiral intermediate in the production of pharmaceuticals and agrochemicals. It is essential for research and development chemists and process engineers in the fine chemical, pharmaceutical, and agrochemical industries seeking to introduce trifluoromethyl and cyanohydrin functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in display technologies.
• Advanced Material Monomers: Employed in the synthesis of specialized polymers and coatings with unique chemical resistance and surface properties.
• Asymmetric Catalysis Research: A valuable substrate for developing and testing new chiral catalysts and methodologies in academic and industrial R&D settings.
• Fluorine Chemistry Reagent: Utilized in exploratory chemistry to study the introduction of fluorine atoms into complex molecular architectures.

Basic Information

Product Name	1-Cyano-1-Phenyl-2,2,2-Trifluoroethanol
CAS No.	20445-04-9
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	α-Cyano-α-phenyl-2,2,2-trifluoroethanol; 2,2,2-Trifluoro-1-phenylethanol-1-carbonitrile; 1-Phenyl-2,2,2-trifluoro-1-cyanoethanol; 2,2,2-Trifluoro-1-cyano-1-phenylethanol; (RS)-1-Cyano-1-phenyl-2,2,2-trifluoroethanol; (±)-1-Cyano-1-phenyl-2,2,2-trifluoroethanol; Trifluoromethylphenylcyanohydrin; TFPCN
EINECS	Contact for details

Quality Control

Our 1-Cyano-1-Phenyl-2,2,2-Trifluoroethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards for reliable integration into regulated synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.