Description

1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetyl Chloride is a high-purity, reactive chemical intermediate characterized by its indole-based structure and acid chloride functional group. This compound is critically important for its role as a key building block in the synthesis of complex pharmaceutical molecules, particularly non-steroidal anti-inflammatory drugs (NSAIDs) and other biologically active agents. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in advanced organic synthesis and active pharmaceutical ingredient (API) development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of indomethacin and related indole-3-acetic acid derivative drugs.
• Custom Synthesis & Research: Serves as a versatile building block for medicinal chemists in drug discovery programs targeting inflammation and pain.
• API Development: Used in the pilot-scale and commercial-scale production of non-steroidal anti-inflammatory drug (NSAID) active ingredients.
• Biochemical Research: Employed in the study of cyclooxygenase (COX) enzyme inhibitors and the development of new therapeutic agents.
• Fine Chemical Manufacturing: Integral to the production of specialized, high-value fine chemicals with complex indole scaffolds.

Basic Information

Product Name	1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetyl Chloride
CAS No.	20357-37-3
Molecular Formula	C20H17Cl2NO3
Molecular Weight	390.26 g/mol
Synonyms	Indomethacin Acid Chloride; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl Chloride; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl Chloride; 3-Acetyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole Chloride; 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Chloride; NSC 198087; Indomethacin Precursor; 1H-Indole-3-acetyl chloride, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliable quality and batch-to-batch consistency for critical pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.