Description

Tolpiprazole CAS NO 20326-13-0 is a high-purity pharmaceutical intermediate belonging to the benzimidazole class of compounds. This compound is of significant commercial importance for its role in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of proton pump inhibitors (PPIs) and related therapeutic agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the research and development of novel benzimidazole-derived drugs.
• Biochemical Research: Serves as a reference standard and a reagent in pharmacological and metabolic studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects.

Basic Information

Product Name	Tolpiprazole
CAS No.	20326-13-0
Molecular Formula	C16H14FN3O2S
Molecular Weight	331.36 g/mol
Synonyms	2-[[(3,5-Dimethyl-4-methoxypyridin-2-yl)methyl]sulfinyl]-5-fluorobenzimidazole; Tolpiprazole; Tolpiprazol; AG-1749; LY-307640; L-307640
EINECS	Contact for details

Quality Control

Our Tolpiprazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product is tested against rigorous in-house specifications, with a focus on identity, potency, and impurity profiles typical for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), residual solvents, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be kept in the original outer packaging or a dark place. Keep away from heat and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.