Description

5-Methoxycarbonylmethyl-2-Thiouridine is a modified nucleoside derivative, a key building block in advanced organic synthesis and pharmaceutical research. Its primary value lies in its role as a versatile intermediate for the development of novel therapeutic agents, particularly in antiviral and anticancer research. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, specialized nucleoside analogs for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for probing RNA structure and function.
• Antisense Oligonucleotide Synthesis: Serves as a modified monomer for the production of therapeutic oligonucleotides with enhanced properties.
• Prodrug Development: Utilized in creating prodrug forms of active nucleoside analogs to improve bioavailability and targeting.
• Labeled Compound Synthesis: Acts as a starting material for incorporating radioactive or stable isotopes (e.g., C-13, N-15) for tracer studies.
• Academic & Industrial R&D: Fundamental building block for exploring new chemical entities and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	5-Methoxycarbonylmethyl-2-Thiouridine
CAS No.	20299-15-4
Molecular Formula	C12H16N2O7S
Molecular Weight	332.33 g/mol
Synonyms	2-Thio-5-carboxymethyluridine methyl ester; 5-(Methoxycarbonylmethyl)-2-thiouridine; 2-Thiouridine, 5-(carboxymethyl)-, methyl ester; 5-Carboxymethyl-2-thiouridine methyl ester; Uridine, 5-(carboxymethyl)-2-thio-, methyl ester; 5-Methoxycarbonylmethyl-2-thiouridine; 2-Thio-5-(methoxycarbonylmethyl)uridine
EINECS	Contact for details

Quality Control

Our 5-Methoxycarbonylmethyl-2-Thiouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements. Our quality commitment aligns with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.