Description

Nicotinoyl Chloride Hydrochloride is a key reactive intermediate in organic synthesis, valued for its role in introducing the nicotinoyl (vitamin B3) moiety into target molecules. This compound is essential for the production of various pharmaceuticals, agrochemicals, and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, nutraceutical, and specialty chemical industries for synthesizing active pharmaceutical ingredients (APIs) and other complex organic compounds.

Application

• Pharmaceutical Synthesis: A crucial building block for the production of niacin (vitamin B3) derivatives, vasodilators, and other cardiovascular drugs.
• Agrochemical Intermediates: Used in the synthesis of novel pesticides and herbicides that require the nicotinic acid structure.
• Biochemical Research: Employed as a reagent for modifying peptides, nucleotides, and other biomolecules to study biological pathways.
• Fine Chemical Production: Serves as a precursor for dyes, photoinitiators, and liquid crystal materials.
• Cosmetic Ingredient Synthesis: Used in the manufacture of certain skin-care actives derived from vitamin B3.

Basic Information

Product Name	Nicotinoyl Chloride Hydrochloride
CAS No.	20260-53-1
Molecular Formula	C6H5Cl2NO
Molecular Weight	178.02 g/mol
Synonyms	Pyridine-3-carbonyl chloride hydrochloride; 3-Pyridinecarbonyl chloride hydrochloride; Nicotinic acid chloride hydrochloride; Nicotinyl chloride hydrochloride; 3-Carbamoylpyridine hydrochloride chloride; Nicotinoyl chloride HCl; 3-Pyridylcarbonyl chloride hydrochloride
EINECS	243-684-7

Quality Control

Our Nicotinoyl Chloride Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality system is designed to meet the rigorous standards required for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	145 - 155 °C (dec.)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.