Description

2-Thiouridine is a modified nucleoside where the oxygen atom at the 2-position of the uracil base is replaced by sulfur. This structural modification is critical for its role in fundamental biochemical research and the development of novel therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in nucleic acid chemistry and molecular biology.

Application

• Biochemical Research: Used as a key building block in the study of RNA structure, function, and stability, particularly investigating the effects of thiolation on base-pairing and duplex formation.
• Pharmaceutical Intermediates: Serves as a precursor in the synthesis of novel nucleoside analogs with potential antiviral, anticancer, or antibacterial activity.
• Probe Development: Incorporated into oligonucleotide probes for studying RNA-protein interactions, folding, and localization due to its distinct physicochemical properties.
• Diagnostic Reagents: Employed in the development of specialized diagnostic kits and assays that require modified nucleotides for enhanced sensitivity or specificity.
• Antisense & RNA Therapeutics: Investigated for use in antisense oligonucleotides and siRNA constructs where backbone modifications can improve nuclease resistance and pharmacokinetic profiles.

Basic Information

Item	Detail
Product Name	2-Thiouridine
CAS No.	20235-78-3
Molecular Formula	C9H12N2O5S
Molecular Weight	260.27 g/mol
Synonyms	2-Thio-uridine; 2-Thiouridylic acid (when referring to phosphate esters); 4-Hydroxy-2(1H)-pyrimidinone riboside, 2-thio-; 1-β-D-Ribofuranosyl-2-thiouracil; 2-Sulfanyluridine; 2-Mercaptouridine; s2U
EINECS	Contact for details

Quality Control

Our 2-Thiouridine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.