Description

7Beta-Hydroxybufalin is a specific, high-purity bufadienolide compound identified by CAS NO 20143-97-9. This specialized steroid derivative is valued for its role as a critical reference standard and active pharmaceutical ingredient (API) intermediate in advanced research and development. It is primarily sought by pharmaceutical R&D laboratories, biotechnology firms, and academic institutions engaged in cardiovascular and oncology studies. The compound's defined structure makes it essential for analytical method development, bioactivity screening, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of bufadienolide-containing preparations.
• Biomedical Research: Serves as a key intermediate or probe in studying Na+/K+-ATPase inhibition and related cellular signaling pathways.
• Cardiotonic Drug Development: Investigated for its potential as a lead compound or precursor in the development of novel heart failure medications.
• Oncology Research: Utilized in in vitro and in vivo studies to explore its apoptotic and anti-proliferative effects on various cancer cell lines.
• Metabolite Studies: Acts as a characterized metabolite or analog in pharmacokinetic and metabolic profiling of toad venom-derived therapeutics.
• Biochemical Reagent: Employed in enzyme inhibition assays and other mechanistic studies within biochemical laboratories.

Basic Information

Product Name	7Beta-Hydroxybufalin
CAS No.	20143-97-9
Molecular Formula	C₂₄H₃₄O₅
Molecular Weight	402.53 g/mol
Synonyms	7β-Hydroxybufalin; Bufalin-7β-ol; 3β,14-Dihydroxy-5β-bufa-20,22-dienolide; 14β,15β-Epoxy-3β,5β,7β-trihydroxy-19-oxo-5β,14β-bufa-20,22-dienolide; NSC 113979; 7β-Hydroxy-14,15β-epoxy-3β,5β-dihydroxy-19-oxobufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 7Beta-Hydroxybufalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.