Description

(2-Fluorophenoxy)Acetyl Chloride is a versatile and highly reactive acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the (2-fluorophenoxy)acetyl moiety, a key structural motif for modulating biological activity and material properties. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides, where the fluorine atom enhances metabolic stability and bioavailability.
• Peptide Mimetics & Drug Discovery: Used to acylate amino groups in the development of peptide analogs and small molecule drug candidates during medicinal chemistry research.
• Liquid Crystal & Polymer Chemistry: Intermediate for synthesizing fluorinated monomers and specialty polymers with tailored optical and electronic properties.
• Chemical Research & Development: A valuable reagent for constructing complex molecular architectures in academic and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	(2-Fluorophenoxy)Acetyl Chloride
CAS No.	2965-17-5
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-(2-Fluorophenoxy)acetyl chloride; Acetyl chloride, 2-(2-fluorophenoxy)-; (o-Fluorophenoxy)acetyl chloride; 2-Fluorophenoxyacetyl chloride; 2-Fluorophenoxyacetic acid chloride; NSC 403119; 2-(2-Fluorophenoxy)ethanoyl chloride
EINECS	Contact for details

Quality Control

Our (2-Fluorophenoxy)Acetyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.