Description

Cholestane-3,7,12,26,27-Pentol is a high-purity, polyhydroxylated sterol derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical intermediate and reference standard for studying bile acid biosynthesis, cholesterol metabolism, and related enzymatic pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in metabolic disorder research and the development of diagnostic assays.

Application

• Biochemical Research Intermediate: A key precursor in the synthesis and study of bile acids and other sterol metabolites.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in drug discovery.
• Metabolic Pathway Studies: Essential for in vitro and in vivo research on cholesterol catabolism and liver function.
• Enzyme Substrate/Inhibitor: Employed in assays to investigate the activity of hydroxylases and other enzymes involved in sterol modification.
• Diagnostic Reagent Development: Used in the formulation of calibrators and controls for clinical diagnostics related to metabolic diseases.
• Academic Research: A valuable tool for universities and research labs focusing on lipid biochemistry and molecular biology.

Basic Information

Product Name	Cholestane-3,7,12,26,27-Pentol
CAS No.	2952-70-7
Molecular Formula	C27H48O5
Molecular Weight	452.67 g/mol
Synonyms	3α,7α,12α,26,27-Pentahydroxy-5β-cholestane; 5β-Cholestane-3α,7α,12α,26,27-pentol; (25R)-3α,7α,12α,26,27-Pentahydroxycholestane; 26,27-Dihydroxycholic acid precursor; 3,7,12,26,27-Pentahydroxycholestane
EINECS	Contact for details

Quality Control

Our Cholestane-3,7,12,26,27-Pentol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and determination of residual solvents and moisture content. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.