Description

2-Amino-9-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)-6-Thiopurine is a key nucleoside derivative and a protected intermediate of significant importance in synthetic organic chemistry. This compound is crucial for researchers and manufacturers requiring a stable, acetyl-protected precursor for the synthesis of modified nucleosides and related bioactive molecules. It is primarily utilized in pharmaceutical R&D for the development of antiviral and anticancer agents, as well as in academic research focused on nucleotide chemistry and biochemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Used in the development and study of purine nucleoside derivatives targeting viral polymerases.
• Biochemical Research: Serves as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Nucleotide Chemistry: Essential for academic and industrial research focused on modifying sugar and base moieties of nucleosides.
• Prodrug Synthesis: Employed in creating prodrug forms of active nucleoside pharmaceuticals to improve bioavailability or stability.
• Reference Standard: Used as a high-purity analytical standard for quality control in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	2-Amino-9-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)-6-Thiopurine
CAS No.	2946-36-3
Molecular Formula	C16H19N5O7S
Molecular Weight	425.42 g/mol
Synonyms	6-Thioguanosine 2',3',5'-Triacetate; 2-Amino-6-mercapto-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; 2-Amino-9-β-D-ribofuranosyl-6-thiopurine 2',3',5'-triacetate; 6-Thio-2-aminopurine riboside triacetate; 2-Amino-6-thiopurine riboside triacetate; NSC 403169; 2-Amino-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine-6-thiol; 6-Mercapto-2-aminopurine riboside triacetate
EINECS	Contact for details

Quality Control

Our 2-Amino-9-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)-6-Thiopurine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.