Description

2-Chloro-2-Phenylacetyl Chloride is a versatile and highly reactive organic acid chloride derivative, serving as a critical building block in advanced chemical synthesis. Its value lies in its dual functional groups, enabling efficient acylation and nucleophilic substitution reactions to construct complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with diphenylacetyl or related structural motifs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators requiring phenylacetyl chloride derivatives.
• Peptide Mimetics & PROTACs: Employed as a coupling agent or linker component in the development of peptide analogs and proteolysis-targeting chimeras (PROTACs).
• Polymer Chemistry: Acts as a monomer or modifying agent for creating specialty polymers with specific thermal or chemical resistance properties.
• Dye & Pigment Manufacturing: Intermediate in the synthesis of complex organic dyes and high-performance pigments.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new organic reactions and synthesizing novel compounds for material science.

Basic Information

Product Name	2-Chloro-2-Phenylacetyl Chloride
CAS No.	2912-62-1
Molecular Formula	C8H6Cl2O
Molecular Weight	189.04 g/mol
Synonyms	α-Chloro-α-phenylacetyl chloride; 2-Chloro-2-phenylacetyl chloride; Phenylchloroacetyl chloride; (Chlorophenyl)acetyl chloride; NSC 406079; Chloro(phenyl)acetyl chloride; 2-Chloro-2-phenylethanoyl chloride
EINECS	220-835-8

Quality Control

Every batch of 2-Chloro-2-Phenylacetyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and highly volatile compound, keep away from heat, sparks, open flames, and incompatible materials such as bases, alcohols, and amines. Use appropriate corrosion-resistant storage equipment and ensure containers are kept upright to prevent leakage.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.