Description

2-Chloro-2,2-diphenylacetyl chloride is a highly reactive acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 2-chloro-2,2-diphenylacetyl moiety, a key structural motif for modifying molecular properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the diphenylacetyl group enhances biological activity.
• Peptide Mimetics & PROTACs: Employed to create sterically hindered carbonyl groups in complex molecules like proteolysis-targeting chimeras (PROTACs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with unique thermal and mechanical properties.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Utilized in the development of organic semiconductors and photoactive materials for electronic applications.

Basic Information

Product Name	2-Chloro-2,2-Diphenylacetyl Chloride
CAS No.	2902-98-9
Molecular Formula	C14H10Cl2O
Molecular Weight	265.13 g/mol
Synonyms	α,α-Dichlorodiphenylacetyl Chloride; Diphenylchloroacetyl Chloride; 2,2-Dichloro-2-phenylethanoyl Chloride; (Dichloro-phenyl-acetyl) chloride; NSC 406079; Chlorodiphenylacetyl Chloride; Benzeneacetyl chloride, α,α-dichloro-
EINECS	220-822-8

Quality Control

Every batch of 2-Chloro-2,2-diphenylacetyl chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA), including results from GC, HPLC, and NMR analyses, is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This compound is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.