Description

Bromotrimethylsilane (CAS NO 2857-97-8) is a highly reactive organosilicon reagent primarily used as a versatile protecting and silylating agent in organic synthesis. Its core value lies in its ability to efficiently introduce the trimethylsilyl (TMS) group, a critical step in the synthesis of complex pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks.

Application

• Pharmaceutical Synthesis: Key reagent for protecting hydroxyl groups during the multi-step synthesis of active pharmaceutical ingredients (APIs) and nucleosides.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides as a silylating agent for sensitive intermediates.
• Polymer & Material Science: Employed as a precursor or modifying agent in the synthesis of silicone-based polymers and specialty materials.
• Natural Product & Peptide Chemistry: Facilitates the protection of functional groups in the complex synthesis of natural products and peptides.
• Analytical Derivatization: Used to silylate compounds for Gas Chromatography (GC) and GC-Mass Spectrometry (GC-MS) analysis to improve volatility and detection.
• Laboratory Research: A fundamental tool in organic chemistry laboratories for method development and small-scale synthesis.

Basic Information

Product Name	Bromotrimethylsilane
CAS No.	2857-97-8
Molecular Formula	C3H9BrSi
Molecular Weight	153.09 g/mol
Synonyms	Trimethylsilyl bromide; TMSBr; Bromo(trimethyl)silane; Trimethylbromosilane; Silane, bromotrimethyl-; NSC 146032; BROMOTRIMETHYLSILICANE
EINECS	220-672-2

Quality Control

Our Bromotrimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥98% (GC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research and commercial grades.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, this product must be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0 %
Density (at 20°C)	1.16 - 1.18 g/mL
Refractive Index (n20/D)	1.423 - 1.425
Water Content (KF)	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.