Description

4-Fluorobenzyl Isothiocyanate is a versatile and reactive organofluorine building block characterized by its isothiocyanate functional group. This compound is essential for the synthesis of thiourea derivatives and other heterocyclic scaffolds, offering a critical pathway for introducing specific molecular motifs. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides by creating bioactive thiourea and heterocyclic derivatives.
• Chemical Biology & Proteomics: Serves as a reactive handle for bioconjugation and labeling of biomolecules due to the specific reactivity of the isothiocyanate group with amines.
• Material Science: Employed in the synthesis of specialty polymers and functional materials that require fluorinated aromatic components.
• Organic Synthesis Reagent: A valuable reagent for constructing sulfur- and nitrogen-containing heterocycles, such as thiazoles and imidazolidine-2-thiones.

Basic Information

Product Name	4-Fluorobenzyl Isothiocyanate
CAS No.	2740-88-7
Molecular Formula	C8H6FNS
Molecular Weight	167.20 g/mol
Synonyms	1-(Isothiocyanatomethyl)-4-fluorobenzene; p-Fluorobenzyl Isothiocyanate; 4-Fluorophenylmethyl Isothiocyanate; (4-Fluorophenyl)methyl Isothiocyanate; NSC 404082; 4-Fluorobenzyl Mustard Oil; 4-Fluoro-α-isothiocyanatotoluene
EINECS	220-368-9

Quality Control

Our 4-Fluorobenzyl Isothiocyanate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications and supporting your research and production quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, amines, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.