Description

Thymidine 3'-Monophosphate Ammonium Salt Hydrate is a nucleotide monophosphate derivative of thymidine, a critical building block in nucleic acid chemistry. This compound is essential for research and development in life sciences, offering a defined and stable precursor for oligonucleotide synthesis and biochemical studies. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic researchers working on nucleotide analogs, DNA synthesis, and molecular biology applications.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor or monomer in the solid-phase synthesis of DNA and RNA strands for research, diagnostics, and therapeutic development.
• Biochemical Research: Used as a substrate or standard in enzymatic studies involving nucleotidyltransferases, kinases, and phosphatases to investigate metabolic pathways.
• Pharmaceutical Intermediates: Acts as a crucial intermediate in the synthesis of nucleotide-based antiviral and anticancer prodrugs.
• Diagnostic Reagent Manufacturing: Incorporated into the production of probes, primers, and other components for PCR, sequencing, and microarray technologies.
• Cell Culture & Media Supplements: Utilized in specialized cell culture media formulations to support the growth of certain fastidious cell lines.
• Reference Standard: Provides a high-purity analytical standard for quality control and method validation in pharmaceutical and biotechnology laboratories.

Basic Information

Product Name	Thymidine 3'-Monophosphate Ammonium Salt Hydrate
CAS No.	2642-43-5
Molecular Formula	C10H19N3O8P • xH2O
Molecular Weight	339.26 g/mol (anhydrous basis)
Synonyms	3'-TMP Ammonium Salt; Thymidine 3'-Phosphate Ammonium Salt; 3'-Thymidylic Acid Ammonium Salt; 2'-Deoxythymidine 3'-Monophosphate Ammonium Salt; dTMP-3' Ammonium Salt; Ammonium Thymidylate (3'); 5-Methyl-2'-deoxyuridine 3'-(dihydrogen phosphate) ammonium salt; TMP-3' NH4+ salt
EINECS	Contact for details

Quality Control

Our Thymidine 3'-Monophosphate Ammonium Salt Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LOD for moisture content, to ensure it meets the high standards required for sensitive research and production applications. Certificates of Analysis (COA) with lot-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	< 0.25 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.