Description

2'-Chloro-2'-Deoxyadenosine is a synthetic nucleoside analog of deoxyadenosine, distinguished by the substitution of a chlorine atom at the 2' position of the sugar moiety. This structural modification is critical for its role as a key pharmaceutical intermediate and a potent biochemical tool in research. It is primarily utilized by manufacturers and research institutions in the life sciences sector for the development of antiviral and anticancer therapeutics, as well as for fundamental biochemical studies involving DNA synthesis and repair mechanisms.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA polymerases, reverse transcriptases, and DNA repair pathways.
• Antiviral Agent Development: Serves as a precursor for compounds investigated for activity against viral infections.
• Oncology Research: Employed in the research and development of chemotherapeutic agents that target DNA replication in cancer cells.
• Molecular Biology: Utilized in the study of nucleic acid metabolism and the mechanisms of nucleoside analog incorporation.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2'-Chloro-2'-Deoxyadenosine
CAS No.	2627-62-5
Molecular Formula	C10H12ClN5O3
Molecular Weight	285.69 g/mol
Synonyms	2'-Chloro-2'-deoxyadenosine; 2'-Cl-2'-dA; 2-Chloro-2-deoxyadenosine; 9-(2-Chloro-2-deoxy-β-D-erythro-pentofuranosyl)adenine; Cladribine Impurity A; 2-CDA; 2'-Chloro-2'-deoxy-β-D-adenosine; NSC 105014
EINECS	220-100-9

Quality Control

Every batch of 2'-Chloro-2'-Deoxyadenosine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.