Description

4'-Thioadenosine is a modified nucleoside analog where the oxygen atom in the ribose sugar's furanose ring is replaced by a sulfur atom. This structural modification is of significant interest in medicinal chemistry and biochemical research, as it can alter the molecule's electronic properties, conformation, and biological activity compared to its natural counterpart, adenosine. It serves as a valuable building block and research tool for scientists in pharmaceutical development and life sciences, particularly in the study of enzyme inhibitors, antiviral agents, and metabolic pathways.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate the mechanism of action of adenosine-metabolizing enzymes like kinases and deaminases.
• Probe Development: Utilized in the design of molecular probes for studying nucleic acid interactions and cellular signaling pathways due to its altered binding affinity.
• Antiviral Research: Investigated for its potential activity against various viruses by interfering with viral replication mechanisms.
• Metabolic Studies: Employed to explore altered metabolic routes and the biological consequences of thio-sugar incorporation into nucleotides.
• Chemical Biology Tool: Serves as a key precursor for synthesizing more complex thionucleosides and oligonucleotide analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4'-Thioadenosine
CAS No.	2500-80-3
Molecular Formula	C10H13N5O3S
Molecular Weight	283.31 g/mol
Synonyms	4'-Thioadenosine; 9-β-D-4'-Thioribofuranosyladenine; 4'-Thio-Adenosine; Adenosine, 4'-thio-; 4'-Thio-D-adenosine; 4'-S-Adenosine; 4'-Thioriboadenosine
EINECS	Contact for details

Quality Control

Our 4'-Thioadenosine is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.