Description

5'-Deoxy-5'-Methylthioadenosine is a naturally occurring nucleoside derivative that serves as a key intermediate in polyamine biosynthesis and the methionine salvage pathway. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a substrate or inhibitor for various enzymes, including methylthioadenosine phosphorylase (MTAP). It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in metabolic studies, enzyme kinetics, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a critical substrate or reference standard in enzymatic assays, particularly for studies involving methylthioadenosine phosphorylase (MTAP) and other enzymes in sulfur metabolism.
• Pharmaceutical Development: Serves as a key intermediate or starting material in the synthesis of novel nucleoside analogs with potential therapeutic applications, including anticancer and antiviral agents.
• Metabolic Pathway Analysis: Employed in laboratory studies to investigate the methionine salvage pathway and polyamine biosynthesis, aiding in the understanding of cellular regulation and disease mechanisms.
• Academic Research: Utilized in universities and research institutes for fundamental studies in biochemistry, molecular biology, and medicinal chemistry.
• Diagnostic Reagent Manufacturing: Can be incorporated into the production of specialized diagnostic kits and reagents for clinical research and biomarker detection.

Basic Information

Product Name	5'-Deoxy-5'-Methylthioadenosine
CAS No.	2457-80-9
Molecular Formula	C11H15N5O3S
Molecular Weight	297.34 g/mol
Synonyms	5'-Deoxy-5'-(methylthio)adenosine; 5'-Methylthio-5'-deoxyadenosine; 5'-S-Methyl-5'-thioadenosine; Methylthioadenosine; MTA; 5'-Deoxy-5'-methylthioadenosine; 5'-(Methylthio)-5'-deoxyadenosine; S-Methyl-5'-thioadenosine
EINECS	219-518-8

Quality Control

Our 5'-Deoxy-5'-Methylthioadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. Our quality system is designed to meet the rigorous standards expected by the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.