Description

2-Chloroquinoline-4-Carbonyl Chloride is a versatile and highly reactive bifunctional organic intermediate. Its value lies in its dual reactive sites—the acid chloride and the chlorinated quinoline ring—which enable efficient synthesis of complex heterocyclic compounds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing quinoline-based drug candidates, including potential antimicrobial, anticancer, and antimalarial agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides that leverage the quinoline scaffold for enhanced activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for metal-organic frameworks (MOFs), and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized quinoline dyes and colorants.
• Cross-Coupling Reactions: The chlorine atom on the quinoline ring makes it a suitable substrate for palladium-catalyzed coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create diverse compound libraries.
• Peptide Mimetics and Bioconjugation: The acid chloride group is reactive towards amines and alcohols, useful for creating peptide-like structures or bioconjugation linkers.

Basic Information

Product Name	2-Chloroquinoline-4-Carbonyl Chloride
CAS No.	2388-32-1
Molecular Formula	C10H5Cl2NO
Molecular Weight	226.06 g/mol
Synonyms	2-Chloro-4-quinolinecarbonyl chloride; 2-Chloroquinoline-4-carboxylic acid chloride; 4-Quinolinecarbonyl chloride, 2-chloro-; 2-Chloro-4-quinolinecarboxylic acid chloride; 2-Chloroquinaldyl-4-carbonyl chloride; 2-Chloroquinoline-4-carboxyl chloride; 2-Chloro-4-carboxyquinoline chloride
EINECS	219-197-5

Quality Control

Our 2-Chloroquinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.