Description

Pentamethonium is a bis-quaternary ammonium compound, specifically a pentamethylene bis-trimethylammonium salt, known for its potent ganglionic blocking activity. This property makes it a critical research tool in pharmacological studies for investigating the autonomic nervous system and cardiovascular physiology. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and chemical manufacturers specializing in fine chemicals and reference standards for drug discovery and mechanism-of-action studies.

Application

• Pharmacological Research: As a classic nicotinic acetylcholine receptor (nAChR) antagonist at autonomic ganglia for studying neurotransmission.
• Neuroscience Studies: Investigation of ganglionic blockade effects on sympathetic and parasympathetic nervous systems.
• Cardiovascular Research: Used in experimental models to induce controlled hypotension and study blood pressure regulation mechanisms.
• Reference Standard: Serves as a high-purity analytical standard in pharmaceutical quality control and method development.
• Fine Chemical Synthesis: Intermediate or building block in the synthesis of more complex quaternary ammonium compounds or specialized pharmaceuticals.
• Biochemical Assays: Tool compound in vitro assays targeting neuronal nicotinic receptors.

Basic Information

Product Name	Pentamethonium
CAS No.	2365-25-5
Molecular Formula	C13H30N2
Molecular Weight	214.39 g/mol
Synonyms	Pentamethonium Dibromide; Pentamethylene-1,5-bis(trimethylammonium); 1,5-Pentanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide; Pentamethonium Bromide; Hexamethonium Homolog; NSC 78966; Pentamethonium (ion); Pentamethonium di-bromide salt
EINECS	219-123-4

Quality Control

Our Pentamethonium is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including identification (IR, NMR), purity assay (HPLC), and control of related substances to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.